Immunogenicity and Safety of IndoVac® as a Heterologous Booster Dose Against COVID-19 in Children 12-17 Years of Age

Tahapan Penelitian : Initial
Sponsor:
Mitra Pelaksana:
Departemen/KSM Ilmu Kesehatan Anak RSHS/FK UNPAD
No Registry
INA-M05FOH8
Tanggal Input Registry : 14-02-2023

24-02-2023
To evaluate immune response to SARS-CoV-2 neutralizing antibody of IndoVac® before and 14 days after booster dose.
- To evaluate SARS-CoV-2 (RBD)-binding IgG antibody titer before and 14 days after booster dose of IndoVac®. - To evaluate antibody persistence at 3, 6, and 12 months after booster dose of IndoVac®. - To evaluate safety profile after booster dose of IndoVac®.
 
Immunogenicity and Safety of IndoVac® as a Heterologous Booster Dose Against COVID-19 in Children 12-17 Years of Age
Immunogenicity and Safety of IndoVac® as a Heterologous Booster Dose Against COVID-19 in Children 12-17 Years of Age
Interventional
Subjects who have previously received complete primary series of inactivated (Sinovac®) COVID-19 vaccine with the last dose administered a minimum of 6 months prior to inclusion but not longer than 12 months prior to inclusion will be given a booster dose of IndoVac vaccine.
150
 

Inclusion Criteria:

1. Clinically healthy children 12-17 years of age. 2. Subjects who have previously received complete primary series of inactivated (Sinovac®) COVID-19 vaccine with the last dose administered a minimum of 6 months prior to inclusion but not longer than 12 months prior to inclusion. 3. Parent/legal guardian and subject has been informed properly regarding the study, and signed the informed consent form (parent/legal guardian) and assent form (subject). 4. Parent and/or legal guardian will commit to comply with the instructions of the investigator and the schedule of the trial.

Exclusion Criteria:

1. Subject concomitantly enrolled or scheduled to be enrolled in another trial. 2. Subject who has received booster dose of COVID-19 vaccine. 3. Subject who has history of COVID-19 in the last 3 months (based on anamnesis or other examinations). 4. Evolving mild, moderate or severe illness, especially infectious disease or fever (body temperature ≥37.5℃, measured with infrared thermometer/thermal gun). 5. History of uncontrolled asthma, history of allergy to vaccines or vaccine ingredients, and severe adverse reactions to vaccines, such as urticaria, dyspnea, and angioneurotic edema. 6. History of uncontrolled coagulopathy or blood disorders contraindicating intramuscular injection. 7. Patients with serious chronic diseases (serious cardiovascular diseases, uncontrolled hypertension and diabetes, liver and kidney diseases, malignant tumors, etc) which according to the investigator might interfere with the assessment of the trial objectives. 8. Subjects who have any history of confirmed or suspected immunosuppressive or immunodeficient state, or received in the previous 4 weeks a treatment likely to alter the immune response (intravenous immunoglobulins, blood-derived products or long-term corticosteroid therapy (> 2 weeks)). 9. Subjects who have history of uncontrolled epilepsy or other progressive neurological disorders, such as Guillain-Barre Syndrome. 10. Subjects receive any vaccination (other than COVID-19 vaccine) within 1 month before and after IP immunization. 11. Female who are pregnant or planning to become pregnant during the study period (judged by self-report of subjects and urine pregnancy test results). 12. Subjects plan to move from the study area before the end of study period.
 
LB.02.01/X.6.5/465/2022
CoV2-Booster-Children-0222
Dr. Eddy Fadlyana, dr.,SpA(K), M Kes