Bioequivalence study of dapagliflozin 10 mg film-coated tablet produced by PT Dexa Medica in comparison with the comparator drug (Forxiga® 10 mg Film-Coated Tablet, manufactured by AstraZeneca Pharmaceuticals LP, USA for AstraZeneca Pharmaceuticals Co. Ltd., China imported by PT AstraZeneca Indonesia, Indonesia).

Tahapan Penelitian : Complete
Sponsor:
Mitra Pelaksana:
No Registry
INA-3KAWTX6
Tanggal Input Registry : 18-09-2023

08-03-2023
To find out whether whether the bioavailability of PT Dexa Medica’s formulation of dapagliflozin 10 mg film-coated tablet is equivalent to that of the comparator drug (Forxiga® 10 mg Film-Coated Tablet, manufactured by AstraZeneca Pharmaceuticals LP, USA for AstraZeneca Pharmaceuticals Co. Ltd., China imported by PT AstraZeneca Indonesia, Indonesia).
 
Bioequivalence study of dapagliflozin 10 mg film-coated tablet produced by PT Dexa Medica in comparison with the comparator drug (Forxiga® 10 mg Film-Coated Tablet, manufactured by AstraZeneca Pharmaceuticals LP, USA for AstraZeneca Pharmaceuticals Co. Ltd., China imported by PT AstraZeneca Indonesia, Indonesia).
Bioequivalence study of dapagliflozin 10 mg film-coated tablet produced by PT Dexa Medica in comparison with the comparator drug (Forxiga® 10 mg Film-Coated Tablet, manufactured by AstraZeneca Pharmaceuticals LP, USA for AstraZeneca Pharmaceuticals Co. Ltd., China imported by PT AstraZeneca Indonesia, Indonesia).
Interventional
Test drug: Dapagliflozin 10 mg film-coated tablet produced by PT Dexa Medica Reference drug: Forxiga® 10 mg Film-Coated Tablet manufactured by AstraZeneca Pharmaceuticals LP, USA for AstraZeneca Pharmaceuticals Co. Ltd., China imported by PT AstraZeneca Indonesia, Indonesia The subjects blood samples will be taken at a certain time. Drug administration, drink and meal for subjects, and subject activities will be standardized during study period.
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Inclusion Criteria:

1. Able to participate, communicate well with the investigators and willing to provide written informed consent to participate in the study. 2. Healthy male and female subjects with absence of significant disease or clinically significant abnormal laboratory values on laboratory evaluation, medical history or physical examination during screening and could be considered healthy based on the evaluation. 3. Aged 18 - 55 years inclusive. 4. Preferably non-smokers or smoke less than 10 cigarettes per day. 5. Body mass index within 18 to 25 kg/m2. 6. Vital signs (after 10 minutes rest) must be within the following ranges: - Systolic blood pressure: 100 - 129 mmHg - Diastolic blood pressure: 60 - 84 mmHg - Pulse rate: 60 - 90 bpm. 7. Willing to practice abstention or contraception during the study

Exclusion Criteria:

1. History of allergy or hypersensitivity or contraindication to dapagliflozin or allied drugs. 2. Pregnant or lactating female (urinary pregnancy test was applied to female subjects at screening and before taking the study drug). 3. Any major illness in the past 90 days or clinically significant ongoing chronic medical illness. 4. Presence of any clinically significant abnormal values during screening e.g. significant abnormality of liver function test (AST, ALT, alkaline phosphatase, total bilirubin, direct bilirubin ≥ 1.5 ULN), renal function test (serum creatinine concentration > 1.4 mg/dL and ureum ≥ 1.5 ULN), etc. 5. Positive Hepatitis B surface antigen (HBsAg), anti-HCV, or anti-HIV. Positive result for COVID-19 rapid antigen test (this criteria will only be applied if the study conduct during pandemic condition). 7. Clinically significant hematology abnormalities. 8. Clinically significant electrocardiogram (ECG) abnormalities. 9. Any surgical or medical condition (present or history) which might significantly alter the absorption, distribution, metabolism or excretion of the study drug, e.g. gastrointestinal disease including gastric or duodenal ulcers or history of gastric surgery. 10. Past history of anaphylaxis or angioedema. 11. History of drug or alcohol abuse within 12 months prior to screening for this study. 12. Participation in any clinical trial within the past 90 days calculated from the last visit to this study’s first dosing day. 13. History of any bleeding or coagulative disorders. 14. Presence of difficulty in accessibility of veins in left or right arm. 15. A donation or significant blood loss within 90 days before this study’s first dosing day. 16. Intake of any prescription drug (especially dapagliflozin and empagliflozin), non-prescription drug (including hormonal contraception), food supplements or herbal medicines within 21 days of this study’s first dosing day
 
KET-1152/UN2.F1/ETIK/PPM.00.02/2022, Amandemen: S-31/UN2.F1/ETIK/PPM.00.02/2023
Not applicable
PPUK/PPUB number
Kartika Widyanty